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However, alanine substituent of four residues Pro458 (P458A), Ser460 (S460A), Ser461 (S461A), and Met462 (M462A) exhibited a significant increase in catalytic activity with no maturational defects (Table 3)

In one embodiment, efficacy of the pharmaceutical formulations described herein maybe evaluated using PROMIS-29, a psychometrically validated 29 item self-report measure of 7 domains

There are a number of proposed mechanisms of gene duplication and amplification 41 , however, none of the models explains the mechanism of duplication in the present case

doi: 10.4103/1008-682X.126386 12 ShamloulRGhanemH

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