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This hydrogen bonding network is not seen in WT-KRAS GDP (PDB Code: 4OBE), or WT-KRAS GppNHp (PDB code: 6GOD)

10.1002/adfm.202419467 [DOI] [Google Scholar] Zhou H., Li Q., Zhang Z., Wang X., Niu H

They've been through rigorous clinical trials

In a murine model of B16F10 cell-induced xenograft melanoma, LSPL-1 triggered an immune response, improved mice survival, and decreased tumor size in a dose-dependent manner

To better understand the pathogenesis and affected systems in both diseases, the role of genes has been investigated

A deeper understanding of these pathways may uncover novel therapeutic targets for IPF, especially those aimed at reversing or modulating metabolic dysregulation in fibrotic lungs