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Additionally, -tocopherol was shown to induce a cytostatic effect on the cell cycle (G0/G1 arrest) in C-6 glioma cells by suppressing extracellular signal-regulated protein kinase 1/2 and protein kinase C (PKC) upstream and retinoblastoma phosphorylation downstream, leading to the suppression of cyclin E and cyclin-dependent kinase (CDK) 2/4 and activation of p27 [99]

doi:10.1080/15384101.2021.2015669 Paik S, Kim JK, Silwal P, et al

& Chanez, P

The monoamine hypothesis of depression has been the main pathophysiology and drug therapy target of depression over the past few decades, but the current monoamine theory has serious limitations (105)