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Thus, ChaC1 is as a key regulator of tumor development, metastasis and responses to chemotherapy, targeted therapy and immunotherapy

This explanation (taken from a website that may no longer be available, so no reference is available) seems reasonable

Cells 12(1):43

doi: 10.3389/or.2025.1671235 Received 22 July 2025 Accepted 11 September 2025 Published 05 November 2025 Volume 19 - 2025 Edited by Priyanka Sharma, University of Texas MD Anderson Cancer Center, United States Reviewed by Lei Yin, Shanghai Jiaotong University School of Medicine, China Sitaramaraju Adduri, University of Texas at Tyler, United States Updates Copyright 2025 Tatode, Chaudhary, Qutub, Trivedi, Umekar, Ali and Premchandani