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As used herein, the terms cell, cells, and a cell expressing NNMT (as used interchangeably herein) refer to one or cells, from any animal, which expresses NNMT, such as, without limitation, rat, mice, monkey, horse, dog, cat, and human

REV-ERB Agonists and Metabolic Regulation: Insights into SLU-PP-332. Journal of Metabolic Research , 45(3), 210-225

Ormond says

Apply an ice pack or a heating pad ($35, amazon.com) as needed for 15 minutes

This is normal for many people