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Separately, GHK-Cu has been found to stimulate fibroblast proliferation while upregulating genes for collagen, elastin, dermatan sulfate, chondroitin sulfate, and decorin key structural components of the skin's extracellular matrix and to modulate matrix metalloproteinases (MMPs) and their inhibitors, which supports balanced remodeling rather than excessive breakdown or fibrosis

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Statistics and reproducibility For all statistical analyses, Origin 2023b was used, where the data distribution was examined with the KolmogorovSmirnov test for two-sample comparison and the group variance was examined with Levenes test for multiple comparisons