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The PPP probably plays a role in the homoeostasis of many vital organs, including heart, kidney, brain, skin and intestine 67,122127

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302,303,304 PINK1 accumulates on the outer membrane of damaged mitochondria and activates parkin, which then ubiquitinates several mitochondrial outer membrane proteins to initiate the autophagic pathway, engulfing damaged mitochondria to maintain mitochondrial health and function

Importantly, none of this research involves human dosing protocols, and no research team has established a standardized administration model appropriate for extrapolation outside laboratory settings