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10.1126/sciimmunol.abj3859 222 WangD.WengY.ZhangY.WangR.WangT.ZhouJ.et al (2020a)

Weeks 6 to 12: optimization The extended phase is about fine-tuning

For example, tau, a pathological hallmark of Alzheimers disease, was observed to successfully degraded in human neurons [179]

Several studies reported an OXPHOS dysfunction and lower mitochondrial membrane potential (MMP) in senescent cells (18, 19, 20, 21, 22, 23), whereas the MMP was found to increase with mitochondrial abundance in these cells (24)

Their functional interplay encompasses transcriptional regulation, oxidative stress modulation, and metabolic reprogramming, profoundly influencing cellular homeostasis and tissue repair

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