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The disulfide bonds in certain proteins are oxidized by ROS which can affect their activity, especially in the tyrosine phosphatases superfamily [25]

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In the ischaemia/reperfusion setting, all mice received B-017 or the negative control peptide intracardially 5 min before and intraperitoneally on consecutive days 1, 3, 5, and 7 of reperfusion

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In this study, participants either were given Module 1 or 2

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Dose escalation typically follows the classic 3 + 3 design, starting from extremely low doses and gradually increasing to higher doses [130]

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