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2002 [updated 2002

doi: 10.1089/neu.2014.3610 64

Clin Pract 7:987

However, numerous mechanisms promote resistance to this therapeutic approach, including enhanced expression of the de novo serine synthesis pathway (SSP) enzymes or activation of oncogenes that drive enhanced serine synthesis

The study measured mRNA levels for MMPs and TIMPs after exposure to the free acid forms of these PGAs, revealing a dose-dependent reduction in TIMP mRNA levels [76]