labial melanotic macule histopathology macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in PDF) Oral melanoacanthoma and oral

Its dysfunction leads to GSH depletion, rendering GPX4 unable to effectively exert its antioxidant function even with adequate expression (Wu et al., 2025a

Vander Jagt DL, Hunsaker LA (2003) Methylglyoxal metabolism and diabetic complications: roles of aldose reductase, glyoxalase-I, betaine aldehyde dehydrogenase and 2-oxoaldehyde dehydrogenase

It is likely that these metabolic inefficiencies will be linked to gene SNPs as well as exposure to environmental pollutants

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While screening for antitumor compounds, the group led by Stockwell BR synthesized and identified two major compound types displaying synthetic lethality with oncogenic RAS in cancer cell lines

Abnormal blood vessels in the esophagus, stomach, or duodenum Conditions such as esophageal varices or gastric varices, which are enlarged and fragile blood vessels, can cause bleeding and result in black, tarry stools