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Despite their prevalence in the human diet, natural antioxidants, particularly dietary flavonoids, have largely failed to demonstrate therapeutic efficacy and may not serve as suitable templates for drug development

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In vivo , lactylation at H4K12la promotes expression of Hif1 and enhances endometrial glycolysis, and in turn forms an H4K12la-Hif1-glycolysis feedback loop to drive decidualization (49)

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Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice