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Gastroenterology 161 , 17641775.e5 (2021)

Other theories on the origin of endometriotic lesions include the embryonic rest theory (prenatal endometrial precursor cells differentiate and become established in the pelvic region) 5,6,7 , coelomic metaplasia (transformation of the peritoneal mesothelium), lymphovascular metastasis (transportation of endometrial cells via lymphatics or blood), or endometrial stem/progenitor cells (reviewed in 8,9,10 )

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For example, consider switching to a VKA when a CYP3A4 or Pgp inhibitor leads to a doubling of the exposure (AUC) of a DOAC, or when an inducer leads to a reduction of at least 20% in its AUC (Steffel et al., 2021

King et al., 2019)

This steady-state assumption induces relations between the rate constants and initial concentrations that, in principle, allow to compute initial concentrations from rate constants