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In malignant tumors, IFN produced by CD8+ T cells increases with rising Gln concentrations, indicating that immunotherapy targeting tumors also relies on Gln-dependent activation of CD8+ T cells ( In the microenvironment of liver cancer tumors, Gln deficiency promotes the invasion of myeloid cells expressing the immunosuppressive receptor GPR109A, facilitating immune evasion

This holistic perspective provides new insights into the pathogenesis of complex diseases and may lead to more integrated therapeutic approaches that consider the interdependence of the gut, brain, and kidneys (Yang et al., 2018)