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Calcium channel Calcium is a critical regulator of cardiac function by maintaining cardiac excitation-contraction coupling, and disturbances in cardiac calcium regulation are a major contributor to left ventricular dysfunction in iron overload cardiomyopathy ( 2+ channels participate in iron uptake into cardiomyocytes (61)

One of the key bioactive compounds found in SPI is genistein, a naturally occurring isoflavone that has been widely studied for its potential health benefits, including anticancer properties (61)

Islam A, Choudhury ME, Kigami Y, Utsunomiya R, Matsumoto S, Watanabe H, Kumon Y, Kunieda T, Yano H, Tanaka J (2018) Sustained anti-inflammatory effects of TGF-1 on microglia/macrophages

However, after surgical removal of the ovaries, the production of these hormones stops completely, which can contribute to additional symptoms like decreased sex drive and fatigue

If this holds true, then UA-lowering drugs may be helpful in prevention/management of diabetes, at least in subjects who are at risk for both hyperuricemia and diabetes

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