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Our previous study using intestine-specific Zip14 KO (IKO) mice revealed that intestinal ZIP14 mediates basolateral uptake of Mn from the bloodstream into enterocytes, contributing to Mn excretion into the intestinal lumen ( 54 Mn was administered subcutaneously, intestinal radioactivity was significantly lower in IKO mice compared to controls, indicating impaired basolateral-to-apical Mn transport

My internist, Sabena Toor, straddles that divide

all tests were two-tailed and = 0.05 for each analysis

Traditional PD and AD cellular models based on immortalized cells and primary neurons as well as animal models based on neurotoxin-induced lesion and viral-mediated transgene overexpression are well characterized, widely accepted, and provide relatively straightforward methods to study disease mechanisms and potential therapeutics

W., Pop-Busui, R

Osteoarthritis: a disease of the joint as an organ