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The findings of this study offer valuable insights for the future development of therapeutic agents targeting hepatocyte ferroptosis, potentially improving targeting accuracy and reducing systemic side effects [223]

FIGURE 2 Epigenetic modifications in key genes related to stress and immunity, such as nuclear receptor subfamily three group C member 1 (NR3C1), TNF, and nuclear factor kappa B (NF-B), modulate both the negative feedback of the HPA axis and inflammatory pathways mediated by NF-B, suggesting a link between endocrine dysregulation and immune activation (Palma-Gudiel et al., 2021)

doi: 10.1021/acsami.3c10620 150

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E-cadherin, a cell adhesion molecule, is upregulated, disrupting tissue integrity and is influenced by the Wnt/-catenin signaling pathway, which affects cell-cell interactions and tissue cohesion