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Consequently, M2-type TAMs within the TIME facilitate iron transport to the extracellular environment, suppress recruitment and cytotoxic function of tumoricidal immune cells, stimulate angiogenesis, and enhance tumor cell proliferation, invasion, and metastasis

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The allure of tumor-released chemotactic factors beckons neutrophils to the tumor site, where tumor-associated neutrophils (TANs) can bolster CD8 + T cell responses and anti-tumor activity in the absence of tumor-derived TGF-