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10.1038/s41420-021-00807-3 69 HealyS.McMahonJ.OwensP.FitzGeraldU

To determine whether ferroptosis contributed to these antitumor effects in vivo, we performed immunofluorescence staining for 4-hydroxynonenal (4-HNE), a marker of lipid peroxidation, in GSC1-derived tumor tissues

This is likely secondary to the well-documented pharmacokinetic properties of Drosophila (and other invertebrate model system) which are distinct from vertebrate counterparts, limiting the ability to dosing studies, etc

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Katikaneni A, Jelcic M, Gerlach GF, Ma Y, Overholtzer M, Niethammer P

Transpiration measurement by water loss The leaves were excised from 45 weeks old plants and then immersed in buffer containing 10 mM MES pH 5.7, 10 mM MgCl 2 , 0.01% Silwet-77, and 2 mM ATP or buffer containing P