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The lower incidence of hepatic dysfunction observed with canakinumab and rilonacept may reflect reduced metabolic stress from their prolonged half-lives (Minoia et al., 2018)

The Acsl4 conditional knockout (cKO) model ( Acsl4 fl/fl Ksp Cre ) was engineered through crossbreeding of Acsl4 fl/fl mice with Ksp Cre transgenic strains, while the Fsp1 fl/fl Ksp Cre cKO mice were generated using analogous breeding strategies

Mast Cell Hyper-Reactivity (MCAS): As a potent antioxidant, glutathione neutralizes the reactive oxygen species that directly trigger mast cell degranulation, helping to stabilize these immune cells and reduce the systemic release of inflammatory mediators