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( e ) RAD51 foci were quantified in FT282 cells expressing empty vector (EV) or MYC treated with the IDH1i, cultured under glutamine starvation (GS), or treated with mildronate (Mildro) alone or supplemented with KG, l-carnitine (l-carn), or O-acetyl-l-carnitine (Ac-Carn

The resulting dysregulation of these proteins is known to compromise sperm-oocyte recognition and promote electron leakage from the electron transport chain, thus exacerbating the level of OS experienced by the spermatozoa 60

Despite these differences that may underlie behavioral abnormalities, direct intranasal administration of dopamine hydrochloride revealed an essentially identical therapeutic profile in both ASD models

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Marzetti E, Calvani R, Cesari M, Buford TW, Lorenzi M, Behnke BJ, Leeuwenburgh C