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(2) Philippou A, Barton ER

The development of less lipophilic drugs with reduced CYP metabolism heightens the potential for metabolism through phase II metabolic routes and consequently involvement of transporters

doi: 10.1186/s40001-025-03196-w 203 MartemucciGCostagliolaCMarianoMDandreaLNapolitanoPDAlessandroAG

The lipophilicity and low molecular weight of DFP enable it to cross the cellular membranes and gain access into cardiomyocytes (Jansov and imnek 2019)