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Although superoxide is the original form of ROS, it is highly unstable, and upon forming, reacts with surrounding molecules to form hydrogen peroxide, peroxynitrite, and all other ROS

Similar to GSDMD, EGFR expression is predominantly localized to SCs 31 , and activation of EGFR is known to trigger downstream signaling via ERK phosphorylation (p-ERK) 31 , a key mediator of cellular responses