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RAS affects a large proportion of the population and has a point prevalence of approximately 23%, daily

Psychiatry 168 , 10901098 (2011)

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Considering that the TNF--induced H 2 O 2 burst has been previously shown to cause oxidative inactivation of JNK phosphatases 54 , JNK hyperactivation is a result of the dual action of GPx1 in regulating H 2 O 2 , which leads to activated ASK1 and inactivated JNK phosphatase

CMAJ 180 , 8148a (2009)