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The most effective prevention strategy combines adequate protein intake (1.0-1.2 grams per kilogram daily), comprehensive micronutrient supplementation from day one, gradual dose titration to moderate the rate of weight loss, maintaining a caloric floor, and baseline blood work to identify and correct pre-existing deficiencies

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Int J Obes 49 , 369380 (2025)

The frequency of B12 injections varies based on individual needs: For deficiency correction: Injections may be administered more frequently, such as weekly or monthly, until levels normalize. For maintenance: Once adequate levels are achieved, monthly injections are typically recommended

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Exp Brain Res 118 : 5260