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Acquired PGA elevation can also occur during chronic acetaminophen use [67, 68] as acetaminophen metabolism consumes glutathione through conjugation reactions, thereby depleting GSH stores and increasing metabolic flux toward PGA formation [69]

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Regulatory and market barriers: Reluctance from pharmaceutical companies to invest in costly trials and difficulties in demonstrating superiority over conventional therapies impede commercialization (54)

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doi: 10.1210/er.2001-0034 8 SchomburgL