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In conclusion, the dorsomedial hypothalamus (DMH)a key GLP-1RA targetmediates pre-ingestive cognitive satiation, while other hypothalamic GLP-1R neurons regulate diverse aspects of feeding behavior, offering potential therapeutic targets for obesity treatment

Bae S, Oh K, Kim H, Kim Y, Kim HR, Hwang YI, et al

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Allosteric modulators of sigma-1 receptor: a review

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The methods mentioned above can be used as a carrier to enhance the efficiency of CRISPR systems by taking advantage of crossing the BBB, therefore possibilities of the target site editing could be improved