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In many patients with severe primary IGF-I deficiency (SPIGFD) defined by low IGF-I (less than 3 SDS or the 2.5 th percentile), severe short stature (Height SDS less than 3), normal GH secretion and absence of acquired insensitivity to GH (discussed below) genetic defects may be absent

NF-B pathway modulation and inflammatory-cytokine response in cell-based models using KPV

25 5 Potential Causes & Contributing Factors The causes of fibromyalgia are still not completely understood, but are likely to involve multiple physiologic, social, and psychological factors

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Ellis CM, Suckling J, Amaro E, Bullmore ET, Simmons A, Williams SC, Leigh PN (2001) Volumetric analysis reveals corticospinal tract degeneration and extramotor involvement in ALS