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Autoimmunity Reviews, 2009

IV administration bypasses the digestive system entirely, allowing your body to absorb significantly more of the active glutathione than it would from an oral supplement, much of which is broken down before it can be absorbed

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The researchers theorized that glutathione depletion may play at least a partial causative role in reduced immune response in people with HIV, and that increasing systemic glutathione could improve immune system function in this group