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Exosomes have been found to include cytokines, proteins, lipids, mRNA, miRNA, non-coding RNA, and ribosomal RNA (Simons and Raposo, 2009)

A master transcription factor in the regulation of glycolysis is hypoxia-inducible factor 1 (HIF-1) because it promotes the transcription of glucose transporters, such as glucose transporter 1 (GLUT1), and glycolytic enzymes, such as hexokinase II (HK-II), and pyruvate kinase M2 (PKM2) (Yu et al., 2017)

Radiographs may show characteristic skeletal changes (hair-on-end skull appearance)

Discussion The observed lower proportional reporting of infections associated with belimumab compared to TNF inhibitors is a notable finding of our analysis