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We argue, based on this and previous studies 28,30,32,79,82 , that this is because inhibition of CPT1 and CPT1A causes both extracerebral (e.g., diminished gut dysbiosis, increased leaked of inflammatory cytokines from the gut, decreased inflammation and oxidative stress in extracerebral organs such as muscles) and intracerebral effects (e.g., decreased inflammation, decreased oxidative stress, decreased bloodbrain barrier disruption, decreased deposition of protein aggregates) (Fig

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