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Taylor & Francis, Boca Raton, pp 1126 Editor information Editors and Affiliations Rights and permissions Copyright information 2012 Springer Science+Business Media, LLC About this chapter Cite this chapter Schmidt, M.M., Dringen, R

The Ataxia Neuropharmacology Committee of the World Federation of Neurology

A higher risk of developing PD has been linked to variants in a number of PARK-designated (SNCA, UCHL1, LRRK2, PARK 16, GAK) and a few additional genes (MAPT, GBA, NAT2, INOS2A, GAK, HLA-DRA, and APOE) (Postuma et al., 2015)

Future work should adopt longitudinal designs to assess therapeutic effects across temporal windows

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The intermediate aspartate semialdehyde can be condensation with pyruvate to participate in the Lys biosynthesis pathway, and homoserine itself can also participate in threonine biosynthesis