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Excessive TrkB activation could alter seizure thresholds, though PE-22-28 appears to have seizure-protective properties that somewhat mitigate this concern

S.KageyamaS.HasegawaJ.IshimuraR.et al (2013)

The peptide does not suddenly become useless on day 29

Some patients choose to have repeated injections in small areas in the face, including around the eye or chin, while others prefer to undergo selective myectomies (cutting of muscles)