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And, pretreatment with Moringa oleifera leaf extract (400 mg/kg/day for 14 days) produced anxiolytic effects in both FST and tail suspension test (TST) in the hepatic encephalopathy mouse model (139)

doi: 10.1016/j.tig.2010.06.006 6 KarczewskiJDobrowolskaARychlewska-HaczewskaAAdamskiZ

Toxicology Reports, 6 , 933939

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And berberine interacts with several liver enzymes called cytochromes specifically CYP2D6, CYP2C9, and CYP3A4, all of which come from cytochrome P450