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Subsequently, the DNA extracted from the cells is fragmented into fragments of 50 to 1000 base pairs by sonication, leaving the bound proteins attached to the DNA

Acknowledgements The authors are grateful to Angelika Sawicka, and Joanna Jaworska, for their technical assistance

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Secondary products that may be relevant to atherogenesis can be thought of in two broad classes: oxidized lipids (primarily oxidized phospholipids but also oxidized cholesterol esters) and reactive lipid aldehydes that exert their effects by modifying proteins and other macromolecules

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The massive quantities of present oxygen enabled the production of more ATP via aerobic respiration but also increased the danger of ROS formation