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Use of dipeptides for the synthesis of glutathione by astroglia-rich primary cultures

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Real-time polymerase chain reaction (PCR) and the enzyme-linked immunosorbent assay (ELISA) analyses revealed significant reductions in mRNA levels and cytokine secretion of IL-1 and IL-6, respectively, following nano-curcumin administration (324)

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15(1):13 Kopustinskiene DM, Bernatoniene J (2021) Molecular mechanisms of melatonin-mediated cell protection and signaling in health and disease

Moreover, this study found that the catalytic triad of GPx4 is located on a flat surface surrounded by basic amino acid patches, K48/K135/R152/T139, and this particular conformation supports its broad-spectrum substrate specificity, and several studies have demonstrated that the molecular weight of GPx4 proteins is 19-22 kDa