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7.4.1.4 Insulin-like growth factor-1 (IGF-1) IGF-1 is a potent neurotrophic factor that is involved in the regulation of neuronal growth and survival

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107,108 In ME2-unexpressed gastric cancer cells, its isoenzyme ME1 is upregulated to replenish intracellular NADPH and promotes cell survival under glucose starvation and anoikis

Monocle2 pseudotime analysis further confirmed that, relative to natural aging, the additional effect of HHcy caused endothelial cells to diverge in different directions and accelerated their transition from pre-aging to senescence, as evidenced by the bifurcation at Branch Point 1 (Figure 2K)