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Hence intracellular proteins usually do not contain disulfides, which are abundant in extracellular proteins (such as those found in blood) or in certain organelles such as the endoplasmic reticulum and mitochondrial intermembrane space where disulfidesc can be introduced

In contrast, unmethylated cytosines are transformed to uracil and in the process, methylated cytosines remain methylated

This usually settles within a week or two

Mol Cytogenet 9:84, 2016

This outcome highlights the substantial challenges encountered during the translation from laboratory research to clinical application

Oxidative stress can cause DNA damage, lipid peroxidation, protein oxidation, and mitochondrial dysfunction (81), all of which are associated with apoptosis in retinal ganglion cells