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Herein, GSH-specific driven nanoplatform is composed of uniform FeOOH nanospindles coated with tetrasulfide bond-bridged mesoporous organosilica (DMOS) shell, and loaded with the HMGB1 inhibitor, glycyrrhizic acid (GA)

4) Underexplored therapeutic strategies and safety concerns: Preclinical studies have relied on short-term administration of ferroptosis modulators, but the long-term safety and efficacy of these agents in ADPKD are unknown

In fact, autophagy activation was confirmed in U251 and U-87MG cells by the increased levels of ATG12 protein (Fig

A lack of vitamin B12 in the body is a type of anaemia, and symptoms can worsen if left untreated

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