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In 2011, Hassanniaasab and colleagues [22] screened human fecal microorganisms for curcumin-converting activity and successfully isolated Escherichia coli , which exhibited the highest activity among the Enterobacteriaceae tested

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An analysis of their structures indicated that the sulfanilamide and amino groups formed three hydrogen bonds with Gly22, Asp103, and Lys106, respectively, except for the classical interactions of the aminopyrimidine backbone with Cys99