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Targeted modulation and enhancement of macrophages via sonodynamic therapy-driven cupferroptosis-like stress for implant-associated biofilm infections

These next-generation maleimides can be used to make thiol-thiol homodimers or to rebridge intramolecular disulfides after their reductive cleavage, but the adducts show lability to excess thiols, and the preparation of heterodimers is not readily achievable under stoichiometric conditions 35,36

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This hierarchical approach leverages the full trial-by-trial dataset while treating participants as random effects, providing robust estimates even in clinical cohorts with limited sample sizes

Random allocation was applied to assign animals to experimental groups

Twenty minutes in water as warm as is comfortable is enough to induce useful sweating