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There are high levels of ketone-metabolizing enzymes in the brain and their capacities for taking up ketone bodies are higher in infancy than in adulthood 18,21

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In this work, we used a combination of biophysical techniques and cryo-electron microscopy (Cryo-EM), showing that human CBS full-length protein polymerises as a filament adopting two very different morphologies dependent on SAM binding and that polymerisation plays a role in both enzyme activation and stability

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