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Most people who follow a healthy diet and consume animal products get enough B12, but some people who follow a vegetarian or vegan diet may not get enough B12 from the foods they eat and might benefit from a vitamin B12 supplement

Rather than resolving hypoxia, these factors activate the expression of genes involved in anaerobic glycolysis (e.g., GLUT1, HK2, LDHA), angiogenesis (e.g., VEGF), invasion (e.g., MMP2, MMP9), and stem cell maintenance

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The winner will depend on Phase 3 data, tolerability, approval timing, label breadth, payer access, and real-world persistence

by R01CA293945 and R01CA257961, respectively