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Dronavalli and Bakris, 2008) suggest that diuretics exert effects beyond the kidneys

56 Studies have shown that Bcl-2 phosphorylation leads to reduced formation of Bax-Bcl-2 heterodimers and activation of the mitochondria-mediated intrinsic caspase cascade

Acknowledgements This work was supported by the National Natural Science Foundation of China (81930112, 81573469)

The methylenetetrahydrofolate reductase enzyme(MTHFR), which is encoded by the MTHFR gene, is a critical enzyme that regulates the metabolism of folate and methionine, both of which are important factors in DNA methylation

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In a study on rats, the administration of 10 mg/kg/day of oral kaempferol was reported to decrease the alveolar bone loss, attachment loss, and gingival tissue MMP-1 and MMP-8 levels [118]