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3.2 Therapeutic potential via paracrine mechanisms The therapeutic effects of MSCs are primarily mediated through their paracrine activity, which involves the secretion of bioactive factorssuch as growth factors, chemokines, cytokines, and EVsto modulate the local microenvironment (Pittenger et al., 2019

Moreover, when NSC (neural stem cell) differentiation-based therapies are combined with NPs, they can help address the complexities of NDs by facilitating tissue regeneration and repair ( Nanomedicine is already proving valuable in treating tumors like glioblastoma, and emerging applications of nanoimmunotherapy are ushering in new opportunities to apply immunotherapy for neurodegenerative conditions (211)