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The biomass of pad2-1 was more affected than that of WT by both AITC and BSO

Importantly, SIRT1 is directly involved in central clock regulation via modulation of transcriptional activity and stability of Per2 and PGC1-mediated Bmal1 expression (69), and SIRT1 signaling disruption has been associated with sleepwake cycle changes in aging (70, 71)

[4] WebMD

Toxins 9:228

The resulting strain W303-1b/gsh1/F (F pathway) together with W303-1b/G (G pathway) and W303-1b/gsh1/pro1 (P pathway) represent different pathway strains (Table 2)