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Bayesian data assimilation has been suggested as a method to integrate patient data and address uncertainty in individualized treatments, a strategy that may also be applicable to peptide-based therapeutics

Thorax 38 , 646656 (1983)

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and it can be tuned up or down by specific gut microbes (such as Akkermansia muciniphila ) [27]

Whether or not every detail of that model is correct, it explains why researchers treated GHK-Cu as a candidate systemic repair signal rather than merely a local additive, and why they were willing to inject it into wound compartments and whole animals to see what a supraphysiologic systemic dose would do

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