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Safety and efficacy of fruquintinib in patients with previously treated metastatic colorectal cancer: a phase Ib study and a randomized double-blind phase II study

doi: 10.1016/j.redox.2024.103345 14 PengXSunBTangCShiCXieXWangXet al

While several mechanisms have been reported, including the release of reactive oxygen species (ROS), inflammatory response, apoptosis, mitochondrial dysfunction, and enhanced blood-brain barrier (BBB) permeability (Zhang et al., 2024b), these findings fail to fully explain the complex processes underlying the onset and progression of HACD

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The coordination chemistry of amino acids is characterized by protonated and polynuclear complexes because the structure of amino acids prohibits all their potential binding sites from being attached to the same metal ion at the same time