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Localization of D2 mRNA in rat brain by in situ hybridization has indicated that the enzyme is expressed in astrocytes, in particular in tanycytes lining the third ventricles (71)

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In GBM, this reaction has effects beyond metabolism: -KG acts as a cofactor for KDM6A, a histone demethylase that removes H3K27me3, a repressive epigenetic molecule