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Neurochemistry 169, e16214

5 4) Tendon & connective-tissue pathways (GHR up-regulation) In tendon fibroblasts, BPC-157 up-regulates the growth-hormone receptor (GHR) at mRNA and protein levels and augments downstream JAK2 signaling in response to GHmechanisms consistent with tendon repair biology (in-vitro)

Many cardiovascular risk factors such as diabetes mellitus, hypertension and hyperlipidemia are demonstrated to stimulate the interaction of Cav-1 and eNOS, reduce nitric oxide production resulting in endothelial dysfunction and subsequently the formation of atherosclerotic lesion 41,42,43